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SARS-CoV-2 and COVID-19


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FDA-approved gout drug could show promise in fighting COVID-19

A gout drug approved by the U.S. Food and Drug Administration (FDA) could reportedly show promise in fighting the coronavirus.

According to a recent study from the University of Georgia (UGA) published in Nature's Scientific Reports, probenecid has potent antiviral properties that make the oral medication a prime candidate to combat not only SARS-CoV-2 infection but other common and deadly respiratory viruses.

The school noted that probenecid is primarily used to treat gout and has been on the market for more than 40 years, with minimal side effects to patients.

"There’s really nothing out there to safely fight these viruses," Ralph Tripp, lead author of the study and GRA Eminent Scholar of Vaccine and Therapeutic Studies in UGA’s College of Veterinary Medicine, said in a statement. "This antiviral works for all RNA respiratory viruses we tested, including SARS-CoV-2. RSV, coronavirus and flu all circulate in the same season. Bottom line is you can potentially reduce infection and disease using this one oral drug."

To be effective, probenecid blocks viral replication, preventing it from infecting an individual's cells. 

In testing, UGA said, the medication works both as a prophylactic prior to virus exposure and as a post-exposure treatment, noting the drug has also proven effective in fighting RSV in vitro.

TrippBio used animal models – hamsters – against SARS-Cov-2 and the flu. 

"Although the drug would primarily be used after a person is positive for the virus, the prophylactic findings mean people with known exposures could also potentially take the drug to prevent getting sick," the university said. 

 

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Australia has gone bye bye Egon. 

Melbourne descends into chaos as police arrest 62 and fire rubber pellets at anti-lockdown protesters

Police have fired pepper balls and stinger grenades at violent anti-Covid lockdown protesters on the streets of Melbourne as Australia’s second-largest city – under stay-at-home orders for the 233rd day in total – descended into chaos.

Protesters dressed as construction workers clashed with police for the second consecutive day on Tuesday, assaulting officers, smashing police car windows, throwing bottles and stones, and damaging property.

https://www.theguardian.com/australia-news/2021/sep/21/victoria-covid-update-melbourne-descends-into-chaos-as-police-fire-rubber-pellets-at-anti-lockdown-protestors

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13 minutes ago, Lhalo said:

Australia has gone bye bye Egon. 

Melbourne descends into chaos as police arrest 62 and fire rubber pellets at anti-lockdown protesters

Police have fired pepper balls and stinger grenades at violent anti-Covid lockdown protesters on the streets of Melbourne as Australia’s second-largest city – under stay-at-home orders for the 233rd day in total – descended into chaos.

Protesters dressed as construction workers clashed with police for the second consecutive day on Tuesday, assaulting officers, smashing police car windows, throwing bottles and stones, and damaging property.

https://www.theguardian.com/australia-news/2021/sep/21/victoria-covid-update-melbourne-descends-into-chaos-as-police-fire-rubber-pellets-at-anti-lockdown-protestors

62 arrests in a city of 5 million?

 

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